What do the Clean, Low, Watch and Swap levels mean?

They are cut from a continuous concern level the app computes from the sourced claims that the chosen evidence lens shows: each claim counts its concern class, tier weight, confidence and dose relevance, combined worst-first with a decay so one serious finding outweighs many small ones, then scaled by how much of the substance reaches you in this use. Clean is below 0.35, Low below 1.1, Watch below 2.0 and Swap above that, on a 0 to 3 scale.

Is Toluene-2 5-Diamine Sulfate safe on skin (rinsed off)?

Q: Is toluene-2 5-diamine sulfate safe on skin (rinsed off)?

Under the app's default Cautious lens, toluene-2 5-diamine sulfate on skin (rinsed off) rates Swap: the app would put this near the top of your swap plan. 3 sourced concerns count (restricted, consensus tier; suspected carcinogen, consensus tier; irritant · allergen, consensus tier). This is research with sources, not medical advice.

Personal care1 use researched3 sourced claims

Where it turns up: hair dye primary intermediate. Detox My Life researched toluene-2 5-diamine sulfate under one use, because the same substance means something different in each use. Every claim below carries its evidence tier, how sure the research is that it applies here, and the sources it cites. The level is computed by the app's own deterministic engine, so the page says exactly what the app would.

Level by use and lens

Use	Mainstream	Cautious (default)	Based	Concerns · favour · fringe
On skin, rinsed off	Swap	Swap	Swap	3 · 0

Mainstream shows consensus claims only; Cautious adds emerging research; Based adds fringe claims, labelled as such. The last column counts, under Cautious, the sourced concerns, the findings in its favour and the fringe claims Based would add.

Safer swaps: the app's swap catalog covers the products this turns up in: Hair dye. Alternatives are always types, never brands.

On skin, rinsed off Swap

Under the default Cautious lens toluene-2 5-diamine sulfate on skin (rinsed off) rates Swap: the app would put this near the top of your swap plan. Mainstream (consensus only) rates it Swap; Based (adds the fringe) rates it Swap. Researched 2026-09-03.

Sourced concerns (3)

ConsensusRestrictedconfidence 100%

Toluene-2,5-diamine sulfate is regulated in cosmetic products in regions like Europe, Canada, and the United Kingdom, listed in Annex III of the EC Cosmetics Regulation, which imposes restrictions and conditions on its use as an oxidative hair dye.

Why here: Its use in rinse-off hair dye products is subject to specific concentration limits and conditions to ensure consumer safety due to its sensitizing properties.
What would have to be true: Use in oxidative hair colouring products at maximum on-head concentrations, for example, up to 2.0% (calculated as free base) or 3.6% (calculated as sulfate salt) in the EU.

Sources the engine cites (no regulator, review or study among them):

1 community or commercial page, not counted here.

ConsensusSuspected carcinogenconfidence 100%

Toluene-2,5-diamine (the free base) is classified as a carcinogen category 1B under EU regulation (EC) No. 1272/2008, indicating it is presumed to have carcinogenic potential for humans.

Why here: This classification applies to the substance, which is used as an oxidative hair dye ingredient, leading to dermal exposure during rinse-off product application.
What would have to be true: Dermal exposure to the substance in hair dye formulations, with maximum on-head concentrations up to 2.0% (calculated as free base) or 3.6% (calculated as sulfate salt).
The other side: The Cosmetic Ingredient Review (CIR) Expert Panel concluded in 2010 that toluene-2,5-diamine and its sulfate salt are safe as hair dye ingredients in the present practices of use and concentrations. The International Agency for Research on Cancer (IARC) classified toluene-2,5-diamine as Group 3 (Not Classifiable as to Human Carcinogenicity) due to inadequate evidence in animals and no data on carcinogenicity in humans. A National Toxicology Program (NTP) bioassay for toluene-2,5-diamine sulfate did not find sufficient evidence to demonstrate carcinogenicity in Fischer 344 rats or B6C3F1 mice under the conditions of the study.

Sources the engine cites:

Final amended report of the safety assessment of toluene-2,5-diamine, toluene-2,5-diamine sulfate, and toluene-3,4-diamine as used in cosmetics - PubMed — nih.gov (2010) · regulator or public body
Provisional Peer-Reviewed Toxicity Values for Provisional Peer-Reviewed Toxicity Values for Toluene-2,5-diamine (CASRN 95-70-5) and Compounds Toluene-2,5-diamine sulfate (6369-59-1) [also known as 1,4-Benzenediamine-2-methyl sulfate or 2- - epa nepis — epa.gov (2010) · regulator or public body
Abstract for TR-126 - National Toxicology Program - NIH — nih.gov (1978) · regulator or public body

ConsensusIrritant · allergenconfidence 100%

Toluene-2,5-diamine sulfate is a strong skin sensitizer and a potent contact allergen, frequently causing allergic contact dermatitis in consumers and hairdressers.

Why here: As an ingredient in oxidative hair dyes, it comes into direct and prolonged contact with the scalp and skin during the application process before being rinsed off.
What would have to be true: Dermal contact during hair dyeing, at concentrations up to 2.0% (as free base) or 3.6% (as sulfate salt) on-head.

Sources the engine cites:

Toluene-2,5-Diamine Sulfate: Allergen of the Year 2025 - PubMed — nih.gov (2025) · regulator or public body
1 community or commercial page, not counted here.

Not researched here

The engine has no dossier for toluene-2 5-diamine sulfate when cooked with heat, in cold food, as a finishing ingredient, in heated food packaging or other uses. The app researches an ingredient for the use it infers from your product, so a scan fills these in; this page only shows what has already been researched and source-verified.

This is research, not medical advice. Detox My Life shows sourced claims sorted by evidence tier. It does not diagnose, treat, or tell you to start or stop anything. Talk to a qualified professional about your health.

Scan your own. The app reads any product label with your camera, works out how you are about to use it, and researches every ingredient for that use with live sources. Every scan adds to a Detox Score for your home, where 50 is a typical home in your region, and a plan of next swaps.

Download on the App Store Get it on Google Play