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Is Cyclohexasiloxane safe on skin (left on)?

Personal care1 use researched2 sourced claims

Where it turns up: volatile silicone, solvent, hair conditioner. Detox My Life researched cyclohexasiloxane under one use, because the same substance means something different in each use. Every claim below carries its evidence tier, how sure the research is that it applies here, and the sources it cites. The level is computed by the app's own deterministic engine, so the page says exactly what the app would.

Level by use and lens

UseMainstreamCautious (default)BasedConcerns · favour · fringe
On skin, left onLowWatchWatch2 · 0

Mainstream shows consensus claims only; Cautious adds emerging research; Based adds fringe claims, labelled as such. The last column counts, under Cautious, the sourced concerns, the findings in its favour and the fringe claims Based would add.

Safer swaps: the app's swap catalog has no entry tied to this ingredient yet. When you scan a product that contains it, the app suggests cleaner alternative types for that product; the swap categories list what the catalog covers today.

On skin, left on Watch

Under the default Cautious lens cyclohexasiloxane on skin (left on) rates Watch: worth watching; the app would list a cleaner alternative type. Mainstream (consensus only) rates it Low; Based (adds the fringe) rates it Watch. Researched 2026-09-03.

Sourced concerns (2)

ConsensusEnvironmentalconfidence 100%

Cyclohexasiloxane (D6) is restricted in leave-on cosmetic products in the EU due to its classification as a very persistent and very bioaccumulative (vPvB) substance, and as persistent, bioaccumulative and toxic (PBT) when containing 0.1% or more by weight of D4, posing a risk of environmental accumulation.

Why here
As a leave-on cosmetic ingredient, cyclohexasiloxane is released into the environment through wastewater after washing, where its persistent and bioaccumulative properties lead to environmental accumulation.
What would have to be true
Dermal exposure from leave-on cosmetic products at concentrations equal to or greater than 0.1% by weight.
The other side
N/A.
Sources the engine cites (no regulator, review or study among them):
  • 1 web article (valutazionesicurezzacosmetici.it), linked in the app.
  • 1 community or commercial page, not counted here.
EmergingIrritant · allergenconfidence 70%

Some individuals with hypersensitive, acne-prone, oily, or reactive skin types may experience mild irritation or breakouts from cyclohexasiloxane, with an estimated comedogenic risk of 4/5.

Why here
When applied to the skin in leave-on products, cyclohexasiloxane remains in contact with the skin, potentially leading to irritation or pore-clogging effects in susceptible individuals.
What would have to be true
Dermal exposure from leave-on cosmetic products.
The other side
Studies have generally found negative results for ocular and skin irritation, skin sensitization, and genotoxicity of D6, and it is considered well-tolerated on skin by some experts.
Sources the engine cites:

Not researched here

The engine has no dossier for cyclohexasiloxane when cooked with heat, in cold food, as a finishing ingredient, in heated food packaging or other uses. The app researches an ingredient for the use it infers from your product, so a scan fills these in; this page only shows what has already been researched and source-verified.

This is research, not medical advice. Detox My Life shows sourced claims sorted by evidence tier. It does not diagnose, treat, or tell you to start or stop anything. Talk to a qualified professional about your health.

Scan your own. The app reads any product label with your camera, works out how you are about to use it, and researches every ingredient for that use with live sources. Every scan adds to a Detox Score for your home, where 50 is a typical home in your region, and a plan of next swaps.

See also: all ingredients · paste a label to check it · how to read an ingredient flag